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J Chromatogr. 1993 Nov 17;621(1):49-53.

Identification of radiolabeled metabolites of nicotine in rat bile. Synthesis of S-(-)-nicotine N-glucuronide and direct separation of nicotine-derived conjugates using high-performance liquid chromatography.

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1
Department of Pharmacology, Pennsylvania State University, College of Medicine, Hershey 17033.

Abstract

Four metabolites of nicotine, including two glucuronides, have been separated by high-performance liquid chromatography. This separation was applied to identification of biliary metabolites of radiolabeled nicotine by radiometric detection. S-(-)-Nicotine N-glucuronide was synthesized and used as a standard in method development.

PMID:
8308087
[Indexed for MEDLINE]

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