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Clin Chim Acta. 1993 Sep 30;218(2):149-58.

Two-dimensional gel electrophoresis of four serum samples from patients with IgD myeloma.

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Department of Biochemistry, Faculty of Medicine, Charles University, Hradec Králové, Czech and Slovak Federal Republic.


Sera containing IgD paraprotein present problems in identifying patients with monoclonal gammopathies because only a small or even no spike may be present on standard serum protein electrophoresis. We have detected heavy chains of IgD monoclonal protein by means of high resolution two-dimensional gel electrophoresis. Besides clearly identifying delta heavy chains in maps of serum proteins, we also found size and charge heterogeneity of monoclonal immunoglobulins. The results demonstrate the usefulness of two-dimensional gel electrophoresis in the analysis of selected cases of immunoglobulin malignancies.

[Indexed for MEDLINE]

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