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Science. 1994 Feb 4;263(5147):689-92.

Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal.

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  • 1Department of Psychiatry, Harvard University, Brockton, MA.

Erratum in

  • Science 1994 Jul 1;265(5168):16.

Abstract

Increased discharge activity of mesopontine cholinergic neurons participates in the production of electroencephalographic (EEG) arousal; such arousal diminishes as a function of the duration of prior wakefulness or of brain hyperthermia. Whole-cell and extracellular recordings in a brainstem slice show that mesopontine cholinergic neurons are under the tonic inhibitory control of endogenous adenosine, a neuromodulator released during brain metabolism. This inhibitory tone is mediated postsynaptically by an inwardly rectifying potassium conductance and by an inhibition of the hyperpolarization-activated current. These data provide a coupling mechanism linking neuronal control of EEG arousal with the effects of prior wakefulness, brain hyperthermia, and the use of the adenosine receptor blockers caffeine and theophylline.

PMID:
8303279
PMCID:
PMC3612520
[PubMed - indexed for MEDLINE]
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