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Free Radic Biol Med. 1994 Jan;16(1):29-33.

The role of O2.- in the production of HO.: in vitro and in vivo.

Author information

1
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.

Abstract

In vitro O2.- reduces Fe(III) to Fe(II), which, in turn, reduces the H2O2, yielding Fe(II)O or HO.. In vivo O2.- increases the supply of free iron by oxidatively attacking the [4Fe-4S] clusters of dehydratases such that they release Fe(II), which can then reduce H2O2. In vivo, O2.- also increases the production of H2O2 by acting as an oxidant toward the dehydratases and toward other cellular reductants.

PMID:
8299992
[Indexed for MEDLINE]

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