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Dev Comp Immunol. 1993 Nov-Dec;17(6):475-81.

A novel adhesion protein expressed by ciliated epithelium, hemocytes, and leukemia cells in soft-shell clams.

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Laboratory for Marine Animal Health, School of Veterinary Medicine, University of Pennsylvania.


The ontogeny of circulating hemocytes and tumor cells in mollusks has been approached using monoclonal antibodies to normal cells. A monoclonal antibody, previously shown to identify an adhesion related protein (p130), has been used to define the reactivity of cells in tissues from normal soft-shell clams (Mya arenaria) and soft-shell clams with leukemia. Using immunoperoxidase technology, we have determined that hemocytes, connective tissue cells, and a subset of leukemia cells that are adherent share a cross-reactive epitope with cilia.

[Indexed for MEDLINE]

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