Format

Send to

Choose Destination
Bioessays. 1993 Nov;15(11):709-13.

Dynamics of DNA methylation during development.

Author information

1
Department of Cellular Biochemistry, Hebrew University, Jerusalem, Israel.

Abstract

DNA methylation plays a role in the repression of gene expression in animal cells. In the mouse preimplantation embryo, most genes are unmethylated but a wave of de novo methylation prior to gastrulation generates a bimodal pattern characterized by unmethylated CpG island-containing housekeeping genes and fully modified tissue-specific genes. Demethylation of individual genes then takes place during cell type specific differentiation, and this demodification may be a required step in the process of transcriptional activation. DNA modification is also involved in the maintenance of gene repression on the inactive X chromosome in female somatic cells and the marking of parental alleles at genomically imprinted gene loci.

PMID:
8292001
DOI:
10.1002/bies.950151103
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center