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Trends Biochem Sci. 1993 Nov;18(11):433-7.

DNA damage and the DNA-activated protein kinase.

Author information

1
Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000.

Abstract

DNA-activated protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase that is activated in vitro by DNA fragments. The cellular targets of DNA-PK are nuclear, DNA-binding, regulatory proteins including Sp1, Fos, Jun, Myc, the tumor suppressor protein p53, and RNA polymerase II. These characteristics suggest a role for DNA-PK in coordinating nuclear processes and as a modulator of checkpoint mechanisms activated by DNA damage.

PMID:
8291090
DOI:
10.1016/0968-0004(93)90144-c
[Indexed for MEDLINE]

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