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Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):709-13.

Function of a human cyclin gene as an oncogene.

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1
Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142.

Abstract

The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.

PMID:
8290586
PMCID:
PMC43018
[Indexed for MEDLINE]
Free PMC Article
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