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J Nat Prod. 1993 Nov;56(11):1878-89.

Antimicrobial compounds from Petalostemum purpureum.

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Department of Pharmacognosy, University of Mississippi, University 38677.


EtOH extracts of Petalostemum purpureum demonstrated antimicrobial activity against bacteria and fungi. Bioassay-directed fractionation led to the isolation of petalostemumol [1] as the active constituent. Its structure was determined by a single crystal X-ray diffraction analysis. A minor component designated petalostemumol G [3] is believed to be an artifact of the isolation procedure. Its structure was confirmed by a single crystal X-ray analysis of its pentamethylether 2. A number of derivatives of 1 and 3, including the Me- and benzylethers and acetates, were prepared.

[Indexed for MEDLINE]

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