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J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):419-27.

Cerebral perfusion and neuropsychological consequences of chronic cocaine use.

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1
Department of Psychiatry, Drew University of Medicine and Science, Los Angeles, CA 90059.

Abstract

Research indicates that cocaine significantly constricts the cerebral vasculature and can lead to ischemic brain infarction. Long-term effects of intermittent or casual cocaine use in patients without symptoms of stroke or transient ischemic attack were investigated. Single-photon emission computed tomography with xenon-133 and [99mTc]hexamethylpropyleneamine oxime, magnetic resonance imaging, and selected neuropsychological measures were used to study cerebral perfusion, brain morphology, and cognitive functioning. Patients were drug free for at least 6 months before evaluation. All showed regions of significant cerebral hypoperfusion in the frontal, periventricular, and/or temporal-parietal areas. Deficits in attention, concentration, new learning, visual and verbal memory, word production, and visuomotor integration were observed. This study indicates that long-term cocaine use may produce sustained brain perfusion deficits and persistent neuropsychological compromise in some subgroups of cocaine-abusing patients.

PMID:
8286941
DOI:
10.1176/jnp.5.4.419
[Indexed for MEDLINE]
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