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Radiology. 1994 Feb;190(2):475-8.

Abdominal diffusion mapping with use of a whole-body echo-planar system.

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Department of Radiology, Harvard Medical School, Boston, MA.



To measure apparent diffusion coefficients (ADCs) of water in liver, spleen, kidney, and muscle.


Ten volunteers (seven women and three men, aged 19-31 years [mean, 24 years]) and nine patients (five women and four men, aged 49-70 years [mean, 62 years]) (liver cyst, n = 3; liver hemangioma, n = 3; liver cirrhosis, n = 2; hepatocellular carcinoma, n = 1; and liver metastasis, n = 1) underwent magnetic resonance (MR) imaging. A stimulated-echo acquisition mode (STEAM)-type excitation and echo-planar imaging (EPI) readout was used in a 1.5-T echo-planar MR imaging system.


ADCs measured in volunteers were liver, 1.39 x 10(-3) mm2/sec +/- 0.16; spleen, 0.95 x 10(-3) mm2/sec +/- 0.15; muscle, 1.99 x 10(-3) mm2/sec +/- 0.16; and kidney, 3.54 x 10(-3) mm2/sec +/- 0.47 (mean +/- standard deviation). Distinctive ADC values were found in organs with abnormalities. ADCs in patients with hepatic disease included liver cysts, 3.9-5.3; liver hemangiomas, 2.0-2.8; liver metastases from an islet cell tumor, 1.2; hepatocellular carcinoma, 1.7; and liver cirrhosis, 0.9-1.2 x 10(-3) mm2/sec.


In vivo diffusion measurements of abdominal organs obtained with MR imaging may prove helpful in the identification and classification of abdominal disease.

[Indexed for MEDLINE]

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