The purpose of this study was a long-term comparison of the dimensional changes of endodontic sealers of diverse properties. The sealers were injected as thin layers on the internal walls of glass pipettes 1 mm in diameter. The pipettes were filled with deionized water, and the water meniscus levels were recorded periodically up to 180 days. The water was removed from the pipettes, samples were allowed to dry, and the mass and the volume of the sealers were measured. AH26 and Endo-Fill had an initial expansion followed by a volumetric loss. The two zinc oxide eugenol-based sealers studied started to shrink within hours after mixing; the first volumetric loss for AH26 was recorded during the first 30 days and for Endo-Fill after 30 days. The least dimensional change at any time was observed for Endo-Fill. It was concluded that a significant dimensional change and continued volume loss can occur in some endodontic sealers.