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J Clin Invest. 1994 Jan;93(1):380-90.

Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission.

Author information

1
Department of Pathology, University of Florida College of Medicine, Gainesville 32610.

Abstract

The extent of nucleotide variation within the HIV-1 env hypervariable domains serves as a marker of virus genotypes within infected individuals and as a means to track transmission of the virus between individuals. We analyzed env V1 and V2 sequences in longitudinal samples from two HIV-1-infected mothers, each with three children infected by maternal transmission of the virus. Sequences in samples that were obtained from two infants at 2 d and 4 wk after birth displayed more variation in V1 and V2 than maternal samples obtained at the same times. Multiple HIV-1 genotypes were identified in each mother. In each family, multiple maternal HIV-1 genotypes were transmitted to the infants. Specific amino acid residues in the hypervariable domains were conserved within sequences from each family producing a family-specific amino acid signature pattern in V1 and V2. Viruses that were highly related to maternal viruses in signature pattern persisted for as long as 4 yr in the older children. Results support a model of transmission involving multiple HIV-1 genotypes with development of genetic variation from differential outgrowth and accumulation of genetic changes within each individual.

PMID:
8282808
PMCID:
PMC293789
DOI:
10.1172/JCI116970
[Indexed for MEDLINE]
Free PMC Article

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