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Indian J Exp Biol. 1993 Sep;31(9):750-4.

Modulation of feeding and drinking by dopamine in caudate and accumbens nuclei in rats.

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Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry, India.


Injection of dopamine (DA) into accumbens and caudate nuclei facilitates a dose-dependent increase in food and water intake, whereas administration of spiperone (SP), a central D2-receptor antagonist suppresses DA-facilitated food and water intake. Bilateral lesions of nucleus accumbens and caudatus result in a sustained and significant decrease in food and water intake. The results suggest that DA is a neurotransmitter involved in feeding and drinking behavior in accumbens and caudate nuclei and this effect is mediated by central D2 receptors.

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