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Gene. 1993 Dec 15;135(1-2):223-8.

The molecular and genetic dissection of the retinoid signalling pathway.

Author information

1
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.

Abstract

Retinoids are derivatives of vitamin A (retinol) that exert a wide variety of profound effects on vertebrate development, cellular differentiation and homeostasis. How these simple molecules can exert such pleiotropic effects has recently been an area of intensive investigation. A complex array of combinatorial effects is beginning to emerge from molecular and genetic studies, which may ultimately account for the pleiotropic effects of retinoids.

PMID:
8276261
DOI:
10.1016/0378-1119(93)90069-f
[Indexed for MEDLINE]

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