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FEBS Lett. 1994 Jan 3;337(1):18-22.

Limited diffusibility of gene products directed by a single nucleus in the cytoplasm of multinucleated myofibres.

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1
Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.

Abstract

Two types of beta-galactosidase genes, whose products are distributed in the nucleus (N beta-gal) or cytoplasm (C beta-gal), were injected with fructose intramuscularly into the quadriceps of adult mice. Regionally restricted and overlapped distributions of both gene products were observed in the myofibres. These findings indicate that N beta-gal is incorporated into the nucleus responsible for its synthesis and that C beta-gal becomes located in the vicinity of the nucleus after its synthesis. This restricted location of C beta-gal in myofibres remained unchanged during the development of infant mouse muscle. Thus, the gene products directed by the nucleus of myofibres seem to show limited diffusibility, suggesting a universal localization of subcellular domains in myofibres.

PMID:
8276105
[Indexed for MEDLINE]
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