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Zhonghua Wai Ke Za Zhi. 1993 Apr;31(4):251-3.

[Effect of radix salviae miltiorrhizae on the mitotic activity of osteoblast-like cells isolated from chicken embryo calvariae cultured in vitro].

[Article in Chinese]

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  • 1Shanghai Institute of Traumatology and Orthopaedics.


Chicken embryo calvariae cultured in vitro, could yield 3 types of osteoblast-like cells, which differed in morphology. They were the spindle-shaped cells, globular cells, and squamous cells. Of these, the squamous cell was the chief cellular component, while both the spindle-shaped cells and the globular cells gradually transformed into squamous cells. Administration of Radix Salviae Miltiorrhizae rendered more rapid growth of the osteoblast-like cells in the early stage of culture. After 17-day of culture, when both the control group cells and the treated, group cells became quite confluent, 3H-Thymidine labelling and radioautographic study revealed a very statistically significant increase in the number of cells, bearing silver grains over the nucleus area in the treated group, as compared with the control (P < 0.001). Since osteoblasts play a pivotal role in fracture healing, administration of Radix Salviae Miltiorrhizae can exert favourable influence on bone repair through increasing the number of osteoblasts.

[PubMed - indexed for MEDLINE]
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