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Am J Gastroenterol. 1994 Jan;89(1):43-6.

Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis.

Author information

1
First Department of Gastroenterology, Evangelismos Hospital, Athens, Greece.

Abstract

OBJECTIVES:

The aim of this study was to evaluate the role of metronidazole and tobramycin as an adjunct to corticosteroids in acute, severe ulcerative colitis.

METHODS:

Thirty-nine consecutive patients with severe ulcerative colitis were randomized on admission to the hospital to receive intravenously either metronidazole (0.5g tid) and tobramycin (4 mg/kg tid) (n = 19), or placebo (n = 20). In addition, they were given parenteral nutrition, intravenous hydrocortisone (100 mg qid) and hydrocortisone enemas (100 mg bid). All patients were assessed after 10 days of continuous treatment, or at any time a severe complication occurred.

RESULTS:

Twelve of 19 patients (63.15%) treated with antibiotics and 13/20 patients (65%) with placebo showed substantial improvement. Seven patients in each group did not improve (n = 9), or developed complications (n = 5) and underwent emergency colectomy without perioperative deaths or late deaths.

CONCLUSIONS:

These results do not support the routine use of intravenous tobramycin and metronidazole in the treatment of severe ulcerative colitis.

PMID:
8273796
[Indexed for MEDLINE]

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