Intrapulmonary delivery of renin inhibitory peptides results in sustained release because of saturable transport

Pharm Res. 1993 Oct;10(10):1548-51. doi: 10.1023/a:1018952131719.
No abstract available

MeSH terms

  • Absorption
  • Animals
  • Biological Transport
  • Drug Delivery Systems
  • Injections, Intraperitoneal
  • Injections, Intravenous
  • Lung / metabolism*
  • Male
  • Oligopeptides / administration & dosage*
  • Oligopeptides / metabolism*
  • Oligopeptides / pharmacokinetics
  • Oligopeptides / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Renin / antagonists & inhibitors*
  • Trachea / metabolism*

Substances

  • Oligopeptides
  • U 77436
  • ditekiren
  • Renin