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Eur J Surg Oncol. 1993 Dec;19(6):641-5.

Results of preoperative neoadjuvant chemotherapy and surgery in the management of patients with soft tissue sarcoma.

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Department of Surgery, National Institute of Oncology, Budapest, Hungary.


Between 1977 and 1991 653 patients were treated for soft tissue sarcoma. Since 1985 limb saving surgery following preoperative neoadjuvant regional chemotherapy has taken place in 53 patients with stage III/A,B disease. In 56.6% (30 patients) treatment was indicated by tumour recurrence. Intra-arterial chemotherapy cycles were performed with doxorubicin (ADM) and cisplatin (cDDP) in the form of rapid infusion. In 25 patients (47%) partial or complete remission (PR,CR) and in 28 patients (53%) minimal response (MR) could be observed. Following neoadjuvant therapy 52 patients underwent limb saving surgery. The patients were followed up for 3-77 months. Due to recurrence, reoperation was required in 22.4% of the cases (11/49 patients). Distant metastases developed in 32.6% (16/49 patients). No intraoperative mortality occurred, the perioperative mortality was 5.7% (three patients).

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