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Epidemiol Infect. 1993 Dec;111(3):483-90.

The coccoid forms of Helicobacter pylori. Criteria for their viability.

Author information

1
Department of Internal Medicine I, University of Ulm, Germany.

Abstract

The fact that Helicobacter pylori can revert to a coccoid form has stimulated speculation about its role in transmission and as a possible cause of reinfection in duodenal ulcer disease. Bismuth subcitrate (32 micrograms/ml), bismuth subsalicylate (64 micrograms/ml), amoxicillin (0.05 micrograms/ml) and erythromycin (4 micrograms/ml) inhibited the growth of H. pylori and stimulated the formation of basically respiring but non-culturable coccoid structures. The presence of polyphosphates as energy and phosphorus source permits a certain level of endogenous metabolism to preserve RNA and DNA, as well as structural components like cell wall, cell membrane and cytoplasma for at least 3 months. However, the applied standard laboratory methods were insufficient for regrowth of H. pylori out of the coccoid form.

PMID:
8270008
PMCID:
PMC2271265
DOI:
10.1017/s0950268800057216
[Indexed for MEDLINE]
Free PMC Article

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