Abstract
The effects of central cyproheptadine and propranolol were virtually the same but differed in their intensity. Differences between genotypes were shown to be able to determine the differences in effects of the blocking agents on different kinds of stress-induced stomach damage. The data obtained suggest that genotypic properties of the serotoninergic system can interfere considerably with the reactions of the stomach mucosa to emotional stress.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Creatinine / administration & dosage
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Cyproheptadine / administration & dosage
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Cyproheptadine / pharmacology*
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Drug Combinations
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Gastric Mucosa / drug effects*
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Injections, Intraventricular
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Male
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Mice
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Mice, Inbred Strains / physiology*
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Peptic Ulcer Hemorrhage / etiology
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Peptic Ulcer Hemorrhage / physiopathology
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Propranolol / administration & dosage
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Propranolol / pharmacology*
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Restraint, Physical
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Serotonin / administration & dosage
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Stomach Ulcer / complications
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Stomach Ulcer / etiology*
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Stomach Ulcer / physiopathology
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Stress, Psychological / complications*
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Stress, Psychological / physiopathology
Substances
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Drug Combinations
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creatinine sulfate, serotonin drug combination
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Cyproheptadine
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Serotonin
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Propranolol
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Creatinine