Format

Send to

Choose Destination
Biochemistry. 1993 Dec 21;32(50):13761-6.

Structure of toxic shock syndrome toxin 1.

Author information

1
Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455.

Abstract

The three-dimensional structure of toxic shock syndrome toxin 1 (TSST-1) from Staphylococcus aureus has been determined and refined to an R value of 0.226 for data between 8- and 2.5-A resolution. Overall, the structure of TSST-1 is similar to that of another superantigen, staphylococcal enterotoxin B (SEB). The key differences between these molecules are in the amino termini and in the degree to which a long central helix is covered by surface loops. The region around the carboxyl end of this central helix is proposed to govern the superantigenic properties of TSST-1. An adjacent region along this helix is proposed to be critical in the ability of TSST-1 to induce toxic shock syndrome.

PMID:
8268150
DOI:
10.1021/bi00213a001
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center