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Trends Biochem Sci. 1993 Jul;18(7):239-43.

The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia?

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  • 1Max-Planck-Institut für Psychiatrie, Abteilung Neurochemie, Martinsried, FRG.


By analogy with epidermal growth factor and EGF-like repeats, the P-domain, or trefoil motif, is a characteristic shuffled module containing six invariant cysteine residues that forms the basic unit for a family of mucin-associated peptides. These P-domain peptides are potential modulators of cell growth and they are also expressed under certain pathological conditions. Furthermore, P-domains have been found as components of extracellular mosaic proteins including certain mucins, where they are thought to play a role either in protein-protein or in lectin-like interactions.

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