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Pharmacol Biochem Behav. 1993 Oct;46(2):453-7.

Nicotine and brain-stimulation reward: interactions with morphine, amphetamine and pimozide.

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Laboratory of Behavioral Pharmacology, Boston University School of Medicine, MA 02118.


Using a rate-independent discrete trial method of determining thresholds for rewarding electrical intracranial stimulation in rats, we evaluated the pharmacological interaction of nicotine plus morphine, d-amphetamine, or the D2 receptor antagonist, pimozide. Both morphine and amphetamine shifted the dose-response curve for nicotine down and to the left, indicating increased efficacy and potency, respectively. Pimozide at doses that have no effect on performance and only minimal effect on brain-stimulation reward blocked the effect of nicotine. These data suggest that the same dopaminergic substrate that supports the positive reinforcing effects of other drugs of abuse also supports nicotine reward.

[Indexed for MEDLINE]

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