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J Biomed Mater Res. 1993 Nov;27(11):1409-18.

Mechanisms of polymer degradation in implantable devices. 2. Poly(DL-lactic acid).

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1
Department of Clinical Engineering, Royal Liverpool University Hospital, United Kingdom.

Abstract

The hydrolytic degradation of poly(DL-lactic acid) in an aqueous environment in which hydroxyl radicals have been generated has been investigated. Different methods (gel permeation chromatography, differential scanning calorimetry, and scanning electron microscopy) were employed to study the mechanisms of degradation of this amorphous physiologically absorbable polymer. The data indicated that the hydroxyl radical is likely to be a significant factor in the degradation of this polymer.

PMID:
8263003
DOI:
10.1002/jbm.820271108
[Indexed for MEDLINE]
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