Format

Send to

Choose Destination
Eur J Med. 1993 Apr;2(4):209-14.

Enterovirus infections in neonates. A retrospective study of 21 cases.

Author information

1
Service de Néomatologie, Hôpitaux Universitaires de Strasbourg, France.

Abstract

OBJECTIVES:

The aim of this study was to define the major features of enterovirus infections in the neonatal period based on our own experience.

METHODS:

Epidemiology, clinical manifestations and laboratory investigations concerning 21 neonates having experienced a Coxsackie B or an Echovirus infection between 1987 and 1991, were retrospectively reviewed. Aetiological diagnosis was made by classical viral isolation and/or by evidencing Coxsackie B-specific IgM antibodies with an immunocapture enzyme immunoassay.

RESULTS:

In 13 neonates the infection occurred between June and September. The onset of clinical signs ranged from day 1 to day 25 after birth with two separate periods: before 7 days of age, suggesting a perinatal transmission of the virus, or beyond this date, more likely connected with a postnatal transmission. Clinical manifestations included hyperthermia, gastroenteritis, meningitis, encephalitis, pneumonia and myocarditis, with a diphasic pattern in 6 cases. Most of the neonates improved gradually and developed normally. The Coxsackie B-specific IgM assay was the most rapid method whereas viral isolation, even though it took more time, was the most sensitive technique to establish the aetiological diagnosis in neonates.

CONCLUSIONS:

Enterovirus infections in neonates are difficult to diagnose and to differentiate from bacterial infections. A viral-like illness in the environment of the neonate allows the clinician to anticipate the clinical signs and a possibly fatal disease. Identification of the causal virus should be performed by both viral isolation and search for specific IgM antibodies. Treatment and prophylaxis are so far disappointing.

PMID:
8261072
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center