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Eur J Immunol. 1993 Dec;23(12):3306-11.

Peripheral clonal deletion of antiviral memory CD8+ T cells.

Author information

1
Department of Pathology, University of Z├╝rich, Switzerland.

Erratum in

  • Eur J Immunol 1998 Sep;28(9):2978-9.

Abstract

Antiviral cytotoxic memory CD8+ T cells adoptively transferred to mice which are persistently infected with lymphocytic choriomeningitis virus WE or DOCILE initially proliferated extensively; they either caused the death of the recipient or, alternatively, disappeared within a few days. Apparently, the complete and coordinated induction and stimulation by widely distributed viral antigen caused these memory T cells to die before virus had been eliminated from the host. Thus memory T cells are as susceptible to peripheral exhaustion/deletion as unprimed T cells. These results indicate possible limitations of exclusively CD8+ T cell-mediated adoptive immunotherapy against viral infections or tumors.

PMID:
8258345
DOI:
10.1002/eji.1830231237
[Indexed for MEDLINE]

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