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Curr Opin Cell Biol. 1993 Aug;5(4):628-35.

Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles.

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University of Heidelberg, Germany.

Erratum in

  • Curr Opin Cell Biol 1993 Dec;5(6):1106.


The formation of constitutive secretory vesicles and secretory granules from the trans-Golgi network is inhibited by brefeldin A, suggesting a role for ADP ribosylation factor and other coat proteins in the budding process, and is regulated by multiple heterotrimeric G proteins. Membrane proteins are sorted to secretory granules through signals in their cytoplasmic domains and, like secretory proteins, by aggregation of their lumenal domains. Synaptic vesicle membrane proteins undergo exocytotic-endocytotic recycling before synapse formation, consistent with the proposed biogenesis of synaptic vesicles from early endosomes.

[Indexed for MEDLINE]

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