Format

Send to

Choose Destination
Annu Rev Microbiol. 1993;47:31-55.

Regulation of sulfur and nitrogen metabolism in filamentous fungi.

Author information

1
Department of Biochemistry, Ohio State University, Columbus 43210.

Abstract

In the filamentous fungi, N. crassa and A. nidulans, complex regulatory circuits control nitrogen metabolism and sulfur metabolism. The expression of entire sets of unlinked structural genes that encode metabolic enzymes is repressed when favored sulfur or nitrogen sources are available. These structural genes are coregulated by global positive-acting regulatory proteins and often are also controlled by metabolic inducers and pathway-specific regulatory proteins. The recent isolation of regulatory genes and representative structural genes of these circuits has provided significant new insight into the operation of both the nitrogen and the sulfur regulatory circuits, which involve sequence-specific DNA binding proteins, promoter control elements, metabolic inducers and repressors, and autogenous regulation.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center