Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann Hum Genet. 1993 Jul;57(Pt 3):169-78.

Germline rearrangement of MCC and APC detected by pulsed field gel electrophoresis and fluorescent in situ hybridization.

Author information

1
Galton Laboratory, Department of Genetics and Biometry, University College London.

Erratum in

  • Ann Hum Genet 1993 Oct;57(Pt 4):311.

Abstract

Pulsed field gel electrophoresis was carried out on lymphocyte DNA obtained from ten patients with the inherited premalignant condition adenomatous polyposis coli and a similar number of control samples to search for large scale molecular rearrangements in the vicinity of the APC locus. DNA from one patient showed a rearranged pattern which was interpreted as evidence for an inversion of approximately 150 kb, changing the transcriptional orientation of the neighbouring MCC gene and bringing it closer to APC. Such an interpretation was supported by fluorescent in situ hybridization data.

PMID:
8257086
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center