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Am J Clin Oncol. 1993 Dec;16(6):492-3.

Echinomycin in recurrent and metastatic endometrial carcinoma. A phase II trial of the Gynecologic Oncology Group.

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  • 1Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157.

Abstract

Twenty-one evaluable patients with recurrent or metastatic endometrial carcinoma were treated with 1,500 micrograms/m2 of echinomycin every 3 weeks. All patients had received prior chemotherapy. There was one complete response (5%), 95% confidence interval for response is 0.9-22.7%. The major toxicity was nausea and vomiting which was moderate to severe in 42% of patients. Myelosuppression was minimal. Echinomycin, in this dose and schedule, displays minimal activity in patients with advanced endometrial carcinoma who have had prior chemotherapy.

PMID:
8256763
[PubMed - indexed for MEDLINE]
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