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Trends Biochem Sci. 1993 Oct;18(10):366-71.

Co-translational protein import into mitochondria: an alternative view.

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Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033.


Recent in vitro and in vivo experiments suggest that the synthesis and import of mitochondrial proteins are very tightly coupled and that a co-translational import reaction may be mandatory for some proteins. These results are entirely consistent with early experiments which suggested that import occurs co-translationally and that cytosolic polysomes synthesizing mitochondrial proteins are bound to protein import sites on isolated mitochondria. This article discusses and seemingly contradictory reports concerning the involvement of co-translational and post-translational mechanisms in the import process and examines the impact of recent developments in the field.

[Indexed for MEDLINE]

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