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Increased anti-Sm antibodies in schizophrenic patients and their families.

Author information

1
Abarbanel Mental Health Center, Bat-Yam, Israel.

Abstract

1. Autoantibodies in the Sm complex have become a useful serologic aid in the diagnosis of systemic lupus erythematosus (SLE) and have rarely been observed in other diseases. 2. A subset of SLE patients have a variety of psychiatric abnormalities, including schizophrenia. 3. The authors have recently observed that schizophrenic patients have a high incidence of autoantibodies suggesting that autoimmune phenomena may play a role in the pathogenesis of this disease. 4. In the present study the authors investigated multicase families with schizophrenia for the presence of anti-Sm antibodies and showed that these autoantibodies are elevated both in patients and in their healthy relatives. 5. An autoimmune process may be involved in the pathology of schizophrenia.

PMID:
8255987
DOI:
10.1016/0278-5846(93)90061-v
[Indexed for MEDLINE]

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