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Biological monitoring of occupational exposure to toluene diisocyanate.

Author information

1
University Institute of Occupational Medicine and Ergonomics, Medical Faculty, La Tronche, France.

Abstract

The study validated the use of urinary toluene diamine (TDA) in postshift samples as an indicator of preceding 8-h exposure to toluene diisocyanate (TDI). Nine workers exposed in TDI-based polyurethane foam production were studied. Their exposure levels varied in 8-h time-averaged samples from 9.5 to 94 micrograms/m3. The urinary TDA concentrations varied from 6.5 to 31.7 micrograms/g creatinine and they were linearly related to the atmospheric TDI levels. Approximately 20% of TDI is metabolized to diamines but their specificity is remarkable to the extent that by analysis for the 2,4- and 2,6-diamino isomers an idea of the percutaneous absorption may be had.

PMID:
8253517
DOI:
10.1007/bf00405726
[Indexed for MEDLINE]

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