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Arthritis Rheum. 1993 Dec;36(12):1697-701.

The effect of long-term methotrexate therapy on hepatic fibrosis in rheumatoid arthritis.

Author information

1
Division of Gastroenterology, University of Utah College of Medicine, Salt Lake City.

Abstract

OBJECTIVE:

To evaluate the progression of hepatic fibrosis in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX).

METHODS:

Fifteen patients receiving MTX for RA were prospectively studied by electron microscopic analysis of biopsy specimens.

RESULTS:

Five of the 15 patients had evidence of increased hepatic collagen after 2 years of MTX therapy.

CONCLUSION:

Hepatic fibrosis may progress in a subgroup of RA patients treated with MTX.

PMID:
8250989
DOI:
10.1002/art.1780361208
[Indexed for MEDLINE]

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