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Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):332-6.

Effects of Achyranthes bidentata polysaccharides on interleukin-1 and tumor necrosis factor-alpha production from mouse peritoneal macrophages.

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Shanghai Institute of Materia Medica, Chinese Academy of Sciences.


Achyranthes bidentata polysaccharides (ABP), extracted from the root of Achyranthes bidentata, induced interleukin-1 (IL-1) synthesis as well as tumor necrosis factor-alpha (TNF-alpha) synthesis and secretion from thioglycolate-primed mouse peritoneal macrophages in vitro. ABP 100-800 enhanced both synthesis and release of IL-1 when stimulated by lipopolysaccharides (LPS) (5, but had no significant influences on synthesis and release of TNF-alpha induced by LPS (10 Studies on IL-1 and TNF-alpha production induced by ABP (200 alone or plus LPS showed that peak levels of IL-1 release reached at 24 h and that of TNF-alpha release at about 2-6 h after incubation. Peritoneal macrophages from mice ip ABP 25 and 50 x 5 d produced much more IL-1 than those from control group. Peritoneal macrophages from ip ABP 100 x 6 d alone released more TNF-alpha vs control group, and showed a synergetic action with LPS (10, which was as strong as the positive control agent BCG. These results provide an explanation for the immunopotentiating effect of ABP.

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