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Trends Pharmacol Sci. 1993 Aug;14(8):308-13.

Molecular basis of muscarinic acetylcholine receptor function.

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National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Laboratory of Bio-organic Chemistry, Bethesda, MD 20892.


Muscarinic acetylcholine receptors play important roles in numerous physiological functions including higher cognitive processes such as memory and learning. Consistent with the well-documented pharmacological heterogeneity of muscarinic receptors, molecular cloning studies have revealed the existence of five distinct muscarinic receptor proteins (M1-M5). Structure-function relationship studies of the cloned receptors have been greatly aided by the high degree of structural homology that muscarinic receptors share with other G protein-coupled receptors. In this review, J├╝rgen Wess discusses recent mutagenesis studies that have considerably advanced our knowledge of the molecular details underlying muscarinic receptor function.

[Indexed for MEDLINE]

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