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Neurosci Lett. 1993 Oct 1;160(2):232-6.

Brain-derived neurotrophic factor expression after long-term potentiation.

Author information

1
Department of Pharmacology, University of Auckland Medical School, New Zealand.

Abstract

Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.

PMID:
8247360
DOI:
10.1016/0304-3940(93)90420-p
[Indexed for MEDLINE]

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