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FEBS Lett. 1993 Nov 22;334(3):269-71.

Interaction of clavulanate with class C beta-lactamases.

Author information

1
Centre d'Ingénierie des Protéines and Laboratorie d'enzymologie, Université de Liège, Belgium.

Abstract

The interactions between clavulanate and three class C enzymes have been studied in detail. In all cases, the reactions followed branched pathways where 25-150 turnovers occurred before inactivation was completed. Reactivation rates were quite low. The poor efficiency of clavulanate as a class C inactivator appeared to rest upon a very slow acylation of the protein, and of a relatively high turnover rate.

PMID:
8243630
DOI:
10.1016/0014-5793(93)80692-n
[Indexed for MEDLINE]
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