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Eur J Pharmacol. 1993 Sep 14;241(2-3):271-3.

Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats.

Author information

1
First Department of Internal Medicine, Miyazaki Medical College, Japan.

Abstract

The hemodynamic effects of human adrenomedullin were investigated in anesthetized Wistar rats. Intravenous administration of adrenomedullin (1.0 nmol/kg) caused a rapid and marked reduction in mean blood pressure associated with a decrease in total peripheral resistance. This reduction in mean blood pressure was closely correlated with the decrease in total peripheral resistance. These findings indicate that human adrenomedullin is a potent vasodilator and may have some role in the regulation of blood pressure.

PMID:
8243562
DOI:
10.1016/0014-2999(93)90214-3
[Indexed for MEDLINE]

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