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Epilepsy Res. 1993 Sep;16(1):55-64.

Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity.

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Institute of Medical Biochemistry, University of Aarhus, Denmark.


Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P < 0.0001) resulting in increased availability of long-chain fatty acids (P = 0.008) due to competitive valproate binding in the valproate-treated patients. The findings support a hypothesis on the pathogenesis of obesity as a complication of valproate treatment of epilepsy.

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