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Cancer. 1993 Dec 1;72(11):3223-6.

Localized invasive pulmonary aspergillosis in patients with neutropenia. Effectiveness of surgical resection.

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1
Department of Hematology, Centre Hospitalier Universitaire Hôtel-Dieu, Nantes, France.

Abstract

BACKGROUND:

Invasive pulmonary aspergillosis (IPA) is a major cause of morbidity and mortality in patients with neutropenia. Two severe complications with poor outcome can be observed after apparently successful IPA medical treatment: severe hemoptysis and IPA relapse during subsequent cytotoxic treatments. Early surgical therapy has not been considered routinely in the management of localized IPA.

METHODS:

Six consecutive patients (four women, two men; median age, 52 years) with localized cavitating IPA diagnosed during chemotherapy-induced aplasia were treated with early surgical resection after hematologic recovery.

RESULTS:

All patients received a lobectomy. Surgery was uneventful. This procedures allows patients to proceed with further intensive chemotherapy and/or bone marrow transplantation without IPA reactivation.

CONCLUSIONS:

For selected patients, surgical resection of localized IPA with unique cavitating lesion, which prevents hemoptysis and IPA recurrence and allows for subsequent cytotoxic treatment, may be recommended.

PMID:
8242545
[Indexed for MEDLINE]
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