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BMJ. 1993 Oct 16;307(6910):988-90.

Adverse reactions to influenza vaccine in elderly people: randomised double blind placebo controlled trial.

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1
Department of General Practice, University of Limburg, Maastricht, Netherlands.

Abstract

OBJECTIVE:

To assess the frequency and type of side effects after influenza vaccination in elderly people.

DESIGN:

Randomised double blind placebo controlled study.

SETTING:

15 general practices in the southern Netherlands.

SUBJECTS:

1806 patients aged 60 or older, of whom 904 received influenza vaccine and 902 placebo.

MAIN OUTCOME MEASURES:

Adverse reactions reported on postal questionnaire completed four weeks after vaccination.

RESULTS:

210 (23%) patients given vaccine reported one or more adverse reactions compared with 127 (14%) given placebo. The frequency of local adverse reactions were 17.5% in the vaccine group and 7.3% in the placebo group (p < 0.001). There was no difference in systemic adverse reactions (11% v 9.4%; p = 0.34). In general, men reported fewer side effects than women.

CONCLUSION:

Only local side effects were more common in vaccinated patients and all side effects were mild.

PMID:
8241913
PMCID:
PMC1679213
[Indexed for MEDLINE]
Free PMC Article
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