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Arthritis Rheum. 1993 Nov;36(11):1603-11.

Phosphocitrate prevents disease progression in murine progressive ankylosis.

Author information

1
Department of Medicine, Minneapolis Veterans Affairs Medical Center.

Abstract

OBJECTIVE:

Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression.

METHODS:

Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle.

RESULTS:

Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC-treated and the saline-treated mice.

CONCLUSION:

PC appears to inhibit disease progression in murine progressive ankylosis.

PMID:
8240437
[Indexed for MEDLINE]

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