Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 1993 Nov;169(5):1226-32.

Blood flow variations in internal carotid and middle cerebral arteries induced by postmenopausal hormone replacement therapy.

Author information

1
Second Obstetrical and Gynecological Department, University of Milan, Italy.

Abstract

OBJECTIVE:

Our purpose was to clarify the mechanisms by which postmenopausal estrogen replacement therapy exerts its protective effect on cardiovascular risk.

STUDY DESIGN:

By means of a bidirectional Doppler ultrasonographic system we measured pulsatility index variations the internal carotid artery and middle cerebral artery in 25 early postmenopausal women during a 6-month period of hormone replacement therapy. Transdermal estradiol (50 micrograms/day) was continuously administered. A 12-day course of medroxyprogesterone acetate (10 mg/day) was added every second month.

RESULTS:

The pulsatility index showed a significant (p = 0.0001) reduction in both arteries after 6 weeks. At 22 weeks a 25% reduction was measured. No variation of the estrogen-induced pulsatility index reduction was observed at the end of every cyclic progestogen supplementation.

CONCLUSIONS:

In early postmenopausal women hormone replacement therapy causes a rapid reduction of pulsatility index in brain arteries. Cyclical progestational supplementation does not modify this positive effect on reactivity of the blood vessels.

PMID:
8238189
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center