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Am J Obstet Gynecol. 1993 Nov;169(5):1223-6.

Excessive estradiol secretion in polycystic ovarian disease.

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Department of Obstetrics and Gynecology, Queens Hospital Center, Jamaica, NY 11432.


Polycystic ovarian disease is both a hyperestrogenic and a hyperandrogenic syndrome, and all studies have shown that hyperestrogenemia is the result of an elevation of estrone with plasma estradiol levels in the normal follicular range. Because a literature search failed to reveal any report of polycystic ovarian disease with significantly elevated estradiol levels, we report a case in which the plasma estradiol was so massively elevated as to mimic an estrogen-producing neoplasm. This case also suggests that although polycystic ovarian disease is a very rare cause of such excessive estradiol production, it should be included in the differential diagnosis of estrogen-producing neoplasms.

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