Format

Send to

Choose Destination
Trends Genet. 1993 Sep;9(9):317-21.

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion.

Author information

1
Max Planck Institut für Immunbiologie, Freiburg, Germany.

Abstract

Classical cadherins are complexed via their cytoplasmic domains with alpha-, beta- and gamma-catenin. This complex formation links cadherins to the actin filament network and to other transmembrane and cytoplasmic proteins. alpha-Catenin is homologous to vinculin, and beta-catenin to the product of the Drosophila gene armadillo, while gamma-catenin seems to be identical to plakoglobin. Catenins are part of a higher order protein structure that is of crucial importance for the adhesive function of cadherins. A working model of the construction and regulation of this multiprotein interaction is proposed.

PMID:
8236461
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center