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Trends Biochem Sci. 1993 Aug;18(8):307-9.

The control of apoptosis in mammalian cells.

Author information

1
Chester Beatty Laboratories, Institute of Cancer Research, London, UK.

Abstract

This article summarizes what is now known, more than 100 years after this prescient observation, of the mechanisms by which death of mammalian cells is regulated. Particular attention is paid to the elimination of self-reactive thymocytes, the induction of cell death during cancer therapy and the mechanism(s) by which cells die following growth factor removal.

PMID:
8236446
DOI:
10.1016/0968-0004(93)90042-l
[Indexed for MEDLINE]

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