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Ophthalmology. 1993 Nov;100(11):1624-8.

Low-dose and high-dose mitomycin trabeculectomy as an initial surgery in primary open-angle glaucoma.

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Department of Ophthalmology, Gifu University School of Medicine, Japan.



The purpose of the study is to determine the optimum regimen of intraoperative administration of mitomycin as an adjunct to trabeculectomy.


Of 11 patients with primary open-angle glaucoma, 22 eyes that had not undergone any surgical intervention were included. In each patient, one eye was randomly allocated to a mitomycin 0.2-mg group and the fellow eye to a mitomycin 0.02-mg group. Mitomycin was applied for 5 minutes only once during trabeculectomy. The follow-up period was 6 to 17 months.


Eleven (100%) eyes in the 0.2-mg group and 7 (63.6%) in the 0.02-mg group achieved successful control of intraocular pressure with or without topical antiglaucoma medication. Transient hypotony maculopathy (18%) and cataract progression (18%) were noted in the 0.2-mg group exclusively. The incidence of other complications was similar between the two groups.


These data suggest that the most appropriate dose of mitomycin for primary surgery seems to be in between the two doses tested in the current study.

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